October 21, 2025

Fall Skincare Secrets: Why Idebenone is Your Magic Key to Hydrated, Glowing Skin

As the vibrant hues of summer fade into the crisp, cool air of **autumn**, our wardrobes aren't the only thing that needs a transition—our **skincare routine** demands a major overhaul, too. The drop in temperature, coupled with lower humidity levels, creates a perfect storm for skin woes like **dryness, flakiness, irritation, and dullness**. You need a powerful defense, a secret weapon to lock in moisture and fend off environmental stress. That weapon? It's the powerhouse ingredient you need to know: **Idebenone**.

At **HygieiaSkin.com**, we believe in proactive, science-backed solutions. This guide will walk you through the essential adjustments for your fall routine and reveal why Idebenone isn't just another buzzword—it's scientifically proven as the **magic key** to achieving great skin during the cool, dry weather months.

The Great Fall Skincare Transition: Why Your Skin is Struggling

Why do you suddenly feel tight and dry once September hits? The main culprits are changes in **humidity** and **temperature**. The natural moisture barrier of your skin, the stratum corneum, is incredibly sensitive to these shifts.

Reduced Humidity: When the air is dry, it literally pulls moisture *out* of your skin in a process called **Transepidermal Water Loss (TEWL)**. This leaves your skin dehydrated and vulnerable.
Heated Indoors: We spend more time indoors with central heating, which is notoriously dry, exacerbating the TEWL.
Wind and Cold: Exposure to harsh wind and cold air can compromise the skin's protective lipid barrier, leading to redness and sensitivity.

To combat this, your routine needs to shift focus from lightweight, water-based products to richer, barrier-repairing, and intensely **antioxidant-rich** formulations.

Essential Fall Skincare Tips for a Healthy Glow ✨

Before introducing our star ingredient, let's nail the foundational steps of your cool-weather routine:

1. Swap Your Cleanser (Go Gentle!)

Ditch the foaming or stripping cleansers that contain harsh sulfates. In the fall, switch to a **cream, balm, or oil-based cleanser**. These are much gentler, cleanse effectively without disturbing the skin's natural oils, and help maintain the crucial moisture barrier.

2. Focus on Layered Hydration

Hydration isn't just about moisturizer; it's about layering! After cleansing, apply a **humectant-rich essence or serum** containing ingredients like **Hyaluronic Acid, Glycerin, or Beta-Glucan**. These ingredients draw moisture into the skin. *Wait a minute for the serum to absorb before moving to the next step.*

3. Choose a Richer Moisturizer (Emollients and Occlusives)

Your lightweight summer gel won't cut it. Look for moisturizers with **emollients** (like ceramides, fatty acids, and squalane) to fill in the cracks in the skin barrier, and **occlusives** (like petrolatum or shea butter) to create a physical seal that prevents moisture loss. This step is non-negotiable for dry skin protection.

4. Don't Skip Sunscreen (Yes, Really!)

Even though the days are shorter and sun intensity may seem lower, **UVA rays** (the aging rays) penetrate clouds and glass all year round. **Daily SPF application** is your best long-term defense against photoaging and is a crucial part of any anti-aging routine.

The Magic Key: Idebenone — The Ultimate Fall Defender

You've perfected the basics, but to truly **optimize your skin’s resilience and radiance** in the face of cool-weather stress, you need a targeted, high-performance ingredient. Enter **Idebenone**.

What is Idebenone?

Idebenone is a synthetic analog of **Coenzyme Q10 (CoQ10)**, but with a smaller molecular structure, which allows it to penetrate the skin more effectively. Its primary function is as one of the most powerful antioxidants available in skincare.

In fact, Idebenone famously topped the *Mitochondrial Antioxidant Index (MAI)*, which measures an antioxidant's effectiveness in protecting skin cells. **It scored significantly higher than popular antioxidants like Vitamin C, Vitamin E, Alpha Lipoic Acid, and CoQ10 itself!** This ranking solidifies its status as a **super-antioxidant**.

The 3 Major Benefits of Idebenone in Cool Weather

1. Unmatched Free Radical Defense 🛡️

The colder months bring unique environmental stressors (like pollution clinging to dry air and thermal fluctuations) that generate **free radicals**. Free radicals are unstable molecules that damage collagen, elastin, and DNA, leading to premature aging and hyperpigmentation.

**Idebenone neutralizes free radicals** at a cellular level, acting as a shield against these environmental aggressors, ensuring your skin remains healthy and stable.

2. Protecting the Lipid Barrier and Hydration

By preventing oxidative stress, Idebenone helps preserve the integrity of the skin's crucial **lipid barrier**. A stronger barrier means **less water loss (TEWL)**, which directly translates to **better hydration, less flakiness, and reduced sensitivity**—exactly what skin needs when facing cold, dry conditions.

3. Targeting Existing Signs of Aging and Dullness

Idebenone doesn’t just protect; it works to correct. Regular use has been shown to improve the appearance of **fine lines, wrinkles, and texture**. By boosting cellular function and fighting oxidative damage that causes dullness, it restores a **vibrant, youthful glow** that the harsh winter air often steals.

Integrate Hygieia Skin's Idebenone Powerhouse into Your Routine

Ready to unlock your skin's fall potential? At HygieiaSkin, we’ve harnessed the full potential of this ingredient in our Idebenone Creams.

Don't let the weather dictate the health and look of your skin. This fall, make the smart, science-backed choice.

October 8, 2025

Idebenone: The Bioactive Antioxidant Transforming Skincare for Women Over 50

When it comes to restoring youthful, radiant skin, few ingredients are as advanced and powerful as Idebenone. Often described as one of the most potent antioxidants ever used in skincare, Idebenone goes beyond what vitamins C and E can do — protecting, repairing, and rejuvenating aging skin at the cellular level. For women over 50, this bioactive compound has become a game-changer, helping to reduce wrinkles, smooth crepey texture, and bring back a firmer, more hydrated appearance. In this article, we’ll explore how Idebenone works, what makes it bioactive, why it’s so effective, and how to use it for maximum results. What Is Idebenone? Idebenone is a synthetic analog of Coenzyme Q10 — a naturally occurring antioxidant in the body that helps generate cellular energy. However, unlike CoQ10, which has a larger molecular structure, Idebenone is smaller and more easily absorbed into the skin. That means it can penetrate deeper, delivering antioxidant power where aging begins: inside the cells. In skincare, Idebenone acts as a bioactive compound — meaning it interacts directly with the skin’s biology to trigger real, measurable changes. It doesn’t just sit on the surface like many topical antioxidants. Instead, it helps protect and repair the skin’s mitochondria, which are responsible for energy production and cell regeneration. This bioactive effect makes Idebenone far more effective at combating the root causes of visible aging, from oxidative stress to collagen loss and barrier breakdown. How Idebenone Works on the Skin Every day, your skin is exposed to UV rays, pollution, and environmental toxins that generate free radicals — unstable molecules that damage collagen, elastin, and DNA. This damage leads to wrinkles, loss of firmness, and the “crepey” texture that becomes more pronounced with age. Idebenone acts like a shield, neutralizing free radicals before they can harm skin cells. But it doesn’t stop there — it also supports the skin’s natural repair process and boosts energy production at the cellular level, allowing damaged cells to recover faster. In simpler terms, Idebenone helps your skin function the way it did years ago — energized, protected, and resilient. Why Idebenone Outperforms Vitamins C and E Vitamin C and Vitamin E have long been praised for their antioxidant properties. They do an excellent job of protecting the skin, but their stability and penetration are limited. Vitamin C oxidizes quickly when exposed to air and light, losing its effectiveness. Vitamin E hydrates well but doesn’t neutralize all forms of oxidative stress. Studies have shown that Idebenone is more powerful than both Vitamin C and E in protecting the skin against environmental and oxidative damage. In fact, one published study in the Journal of Cosmetic Dermatology found that Idebenone provides the highest environmental protection factor (EPF) of any known antioxidant. Here’s a quick comparison: Antioxidant Penetration Stability Antioxidant Power Vitamin C Moderate Low High Vitamin E Moderate Medium Medium Idebenone Deep High Very High Because of its superior stability and molecular design, Idebenone stays active longer and penetrates deeper — making it one of the most effective ingredients for repairing and protecting mature skin. The Science Behind Idebenone’s Effectiveness Clinical research backs up Idebenone’s remarkable results. In a 2005 study published in the Journal of Cosmetic Dermatology, participants who used a 1% Idebenone cream saw: 29% fewer fine lines and wrinkles 26% smoother skin texture 37% higher hydration levels Even at a 0.5% concentration, Idebenone produced significant results — reducing fine lines by 27% and roughness by 23%. These findings show that even small amounts of Idebenone can make a visible difference. Another study found that Idebenone decreased sun-damaged cells by up to 38% when applied before UV exposure, demonstrating its powerful preventive benefits for photodamage and premature aging. Simply put, Idebenone doesn’t just protect your skin — it helps reverse existing damage while preventing new signs of aging from forming. Why Bioactive Ingredients Matter The term bioactive means that an ingredient directly interacts with biological systems in the body — triggering a response or change. Many skincare ingredients are “cosmetic-grade,” meaning they improve the appearance temporarily. Bioactive ingredients like Idebenone go deeper, affecting the actual structure and function of the skin. Idebenone’s bioactive nature means it: Stimulates collagen production for firmer, more elastic skin Improves mitochondrial efficiency for better cell energy Reduces inflammatory damage caused by oxidative stress Supports the skin’s repair mechanisms for smoother texture When applied regularly, Idebenone helps the skin rebuild itself from within, improving tone, texture, and elasticity in a way traditional antioxidants cannot. The Role of Liposomal Delivery in Enhancing Effectiveness Idebenone’s effectiveness depends not only on the ingredient itself but also on how it’s delivered. That’s why advanced formulations like Hygieia’s Crepe Repair Cream use a liposomal delivery system. Liposomes are microscopic, lipid-based spheres that encapsulate Idebenone and other actives. Because liposomes mimic the structure of skin cell membranes, they can merge with them and deliver ingredients directly into deeper layers of the skin. The benefits of liposomal delivery include: Deeper absorption for more noticeable results Slow, sustained release for longer-lasting effects Reduced irritation — even for sensitive skin Enhanced stability and protection of the Idebenone molecule This delivery system makes a major difference, especially for mature skin that’s thinner and more fragile. Liposomal encapsulation allows Idebenone to bypass the skin barrier and deliver its full antioxidant and regenerative potential right where it’s needed most. Why Idebenone Is Perfect for Women Over 50 As we age, the skin’s ability to renew and repair itself slows down. Estrogen levels drop, collagen breaks down, and moisture retention declines. These changes lead to the hallmark signs of mature skin — crepiness, fine lines, dullness, and sagging. Idebenone addresses all of these concerns at once: Fights oxidative stress — protecting against daily damage Stimulates collagen — improving firmness and elasticity Increases hydration — smoothing crepey, thin areas Enhances cellular repair — promoting a more youthful texture Unlike surface moisturizers that offer temporary relief, Idebenone works at a biological level to help the skin behave more like it did years ago. Over time, you’ll notice skin that looks healthier, feels firmer, and glows with renewed vitality. How to Incorporate Idebenone Into Your Skincare Routine If you’re over 50 and looking to rejuvenate your skin, start by adding an Idebenone-rich cream like the Hygieia Crepe Repair Cream to your daily routine. Here’s how to get the most benefit: Apply to clean, dry skin once or twice daily. Use after cleansing and before sunscreen or makeup. Pair with gentle exfoliation 1–2 times per week to boost absorption. Be consistent — results improve with long-term use. Idebenone works best as part of a comprehensive skincare regimen that includes daily sun protection, hydration, and antioxidants. With regular use, you can expect smoother, firmer, and more radiant-looking skin within a few weeks. Real Results, Backed by Science Clinical studies and real-world results continue to support Idebenone as one of the most effective anti-aging ingredients available today. Dermatologists praise it for its ability to improve both the appearance and function of the skin without causing irritation or sensitivity. In short, Idebenone doesn’t just mask signs of aging — it helps your skin function more youthfully from the inside out. The Future of Skincare Is Bioactive Bioactive ingredients like Idebenone represent the next evolution in skincare. Instead of simply coating the surface, they work in harmony with your body’s natural processes — enhancing energy, repairing damage, and optimizing function. When delivered through modern liposomal systems, these actives can achieve results once thought impossible from a topical cream. If you’ve been searching for a formula that truly makes a difference for mature, crepey, or sun-damaged skin, look no further than Idebenone. It’s scientifically backed, clinically proven, and trusted by skincare professionals worldwide. Experience the Power of Bioactive Skincare At Hygieia Skin, we’ve harnessed the power of Idebenone and paired it with our advanced liposomal delivery system to create the Crepe Repair Cream — a formula designed specifically for women over 50 who want smoother, firmer, more radiant skin without invasive treatments. This isn’t just skincare — it’s bioactive skin renewal. Shop Hygieia Crepe Repair Cream and experience the difference for yourself.

Learn more

September 28, 2025

The Power of Peptides in Skincare: Your Ultimate Guide to Firmer, Younger-Looking Skin

The Unsung Heroes of Anti-Aging: Decoding the Power of Peptides In the ever-evolving world of skincare, new ingredients constantly emerge, each promising to be the next fountain of youth. Trends come and go, but some powerhouses stand the test of time, backed by robust science and visible results. At the forefront of this scientifically-proven category are peptides. You've likely seen the word "peptides" emblazoned on serums, moisturizers, and eye creams, but what exactly are these microscopic marvels? And more importantly, how do they work to turn back the clock on your skin? Consider this your ultimate guide to understanding the profound impact of peptides. We'll delve into the science behind how they function, explore the different types and their unique benefits, and show you how to seamlessly integrate them into your routine for skin that looks and feels stronger, smoother, and more resilient. What Exactly Are Peptides? The Building Blocks of Youthful Skin To understand peptides, we first need to talk about proteins. Your skin is composed primarily of proteins, with the most famous being collagen, elastin, and keratin. These proteins are responsible for your skin's structure, firmness, texture, and elasticity. Think of them as the framework that holds everything together. So where do peptides fit in? Peptides are short chains of amino acids, which are the fundamental building blocks of all proteins. You can think of it like this: Amino Acids are the individual letters of the alphabet. Peptides are the words formed by linking these letters together. Proteins are the complete sentences and paragraphs formed by combining these words. When the collagen in your skin breaks down naturally due to age and environmental factors, it forms specific types of peptides. Your body recognizes these peptides as a "signal" that your skin has been damaged and needs to create more collagen. By applying peptides topically in your skincare, you are essentially sending a direct message to your skin cells, telling them to kick into high gear and start rebuilding. The Science of Signaling: Why Peptides Are a Skincare Superhero The true magic of peptides lies in their role as cellular messengers or "cell-signaling agents." Different peptides have different jobs. They can tell your skin to produce more collagen, calm inflammation, improve hydration, or even relax the muscles that cause expression lines. As we age, our natural production of collagen and elastin slows down dramatically. Starting in our mid-20s, we lose about 1% of our collagen each year. This loss, combined with sun exposure and other environmental stressors, leads to the visible signs of aging: fine lines, wrinkles, sagging, and a loss of that youthful plumpness. Skincare containing peptides helps to counteract this process. When absorbed into the skin, these clever molecules act as a bio-hack, essentially tricking your skin into thinking its collagen is breaking down. This prompts the skin's natural healing and regeneration processes, leading to a surge in the production of new, healthy collagen and elastin fibers. The result is a complexion that is visibly firmer, smoother, and more resilient. Not All Peptides Are Created Equal: Exploring the Different Types The term "peptide" is an umbrella for hundreds of different variations, each with a highly specialized function. Understanding the main categories can help you choose products that target your specific concerns. 1. Signal Peptides: The Collagen Boosters This is the largest and most common group of peptides found in anti-aging skincare. As their name suggests, they signal the skin to perform a specific function—most notably, to ramp up the production of collagen, elastin, and other structural proteins. They are the ultimate architects for rebuilding your skin’s foundation from within. What they do: Stimulate fibroblast cells to produce more collagen, leading to increased skin firmness and reduced wrinkle depth. Look for names like: Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Oligopeptide. 2. Carrier Peptides: The Essential Transporters Carrier peptides work by stabilizing and delivering crucial trace elements, like copper and manganese, to the skin. These elements are vital for enzymatic processes involved in wound healing and collagen synthesis. Copper, in particular, is a well-studied ingredient known for its skin-restoring properties. What they do: Enhance wound healing, boost collagen, improve skin elasticity, and provide powerful antioxidant and anti-inflammatory benefits. Look for names like: Copper Tripeptide-1 (GHK-Cu), Manganese Tripeptide-1. 3. Neurotransmitter-Inhibiting Peptides: The Line Smoothers Often marketed as having a "Botox-like" effect, these peptides work on a neuromuscular level. They are designed to block the signals between nerves and facial muscles, causing the muscles to relax. This gentle inhibition helps to soften the appearance of dynamic wrinkles—the lines formed by repetitive facial expressions, like crow’s feet, smile lines, and forehead furrows. What they do: Reduce the appearance of expression lines by limiting muscle contraction. Look for names like: Acetyl Hexapeptide-8 (Argireline), Pentapeptide-18. 4. Enzyme-Inhibiting Peptides: The Collagen Protectors While signal peptides work to build new collagen, enzyme-inhibiting peptides work to protect the collagen you already have. They function by slowing down the activity of enzymes, like matrix metalloproteinases (MMPs), which are responsible for the natural degradation of collagen in the skin. This process is often accelerated by sun exposure. What they do: Help preserve existing collagen, maintaining skin firmness and preventing sagging. Look for names like: Trifluoroacetyl Tripeptide-2, Soybean Peptides. How to Seamlessly Integrate Peptides Into Your Skincare Routine Adding peptides to your daily regimen is simple and highly effective. Here’s how to get the most out of these powerful ingredients: Choose the Right Format: Peptides need to be absorbed by the skin to work their magic. For this reason, they are most effective in leave-on products like serums, moisturizers, and eye creams. Peptide serums are particularly beneficial as they are lightweight, highly concentrated, and designed for deep penetration. Apply to Damp Skin: For optimal absorption, apply your peptide product to clean, slightly damp skin right after cleansing or toning. Consistency is Crucial: Peptides deliver incredible benefits, but they are a long-term investment in your skin’s health. Results won't appear overnight. You need to use your peptide product consistently, both morning and night, for several weeks or months to see a noticeable improvement in skin texture and firmness. Layer Like a Pro: Peptides are team players and work wonderfully with many other skincare ingredients. They pair especially well with: Hyaluronic Acid: For a powerful hydration and plumping boost. Vitamin C: For enhanced antioxidant protection and brightening (look for stable, modern formulas to ensure compatibility). Niacinamide: To support the skin barrier and improve texture. A Note on Exfoliants: While peptides are generally stable, it's best to be mindful when using them with very strong direct acids (like high-concentration AHAs and BHAs). To be safe, you can apply your peptide product at a different time of day than your strong exfoliant (e.g., peptides in the morning, acids at night). Reading the Label: How to Spot Peptides in Your Products Navigating ingredient lists can be intimidating, but finding peptides is easier than you think. Look for words that contain "peptide" or end in "peptide." You'll often see them listed with a prefix that denotes their structure, such as: Tripeptide (composed of three amino acids) Tetrapeptide (composed of four amino acids) Hexapeptide (composed of six amino acids) Palmitoyl (a fatty acid attached to a peptide to increase its stability and skin penetration) The higher up on the ingredient list, the higher the concentration. However, peptides are effective even at very low concentrations, so don't be discouraged if they aren't in the top five ingredients. Frequently Asked Questions (FAQ) Q: Are peptides better than retinol? A: They aren't better; they're different! Retinol works by accelerating skin cell turnover, while peptides work by signaling the skin to build more collagen. They target aging through different pathways and can be incredibly effective when used together in a well-rounded routine. Q: How long does it take for peptides to work? A: With consistent twice-daily use, you may start to see improvements in hydration and texture within 4 to 6 weeks. More significant changes in firmness and wrinkle reduction can take 3 to 6 months as your skin needs time to build new collagen. Q: Are there any side effects to using peptides? A: Peptides are generally very well-tolerated by all skin types, including sensitive skin. They are naturally occurring in the body, so allergic reactions are rare. As with any new product, it's always wise to perform a patch test. The Final Word: Build a Stronger Future for Your Skin Peptides are more than just a passing trend; they are a cornerstone of intelligent, effective anti-aging skincare. By acting as precise messengers, they empower your skin to repair, rebuild, and rejuvenate itself from the inside out. Whether you're looking to smooth fine lines, restore lost firmness, or simply maintain a healthy, resilient complexion, incorporating peptides into your daily ritual is a powerful step towards achieving your long-term skin goals. Unleash the power of these cellular communicators and build a stronger, healthier, and more youthful future for your skin.

Learn more

August 13, 2025

The Antioxidant Powerhouse for Aging Skin: How Idebenone Outperforms Vitamins C & E

The Antioxidant Powerhouse for Aging Skin: How Idebenone Outperforms Vitamins C & E As we age, our skin tells a story. For many women over 50, that story includes fine lines, wrinkles, and the delicate, thin texture often referred to as “crepey skin.” While aging is a natural process, the visible signs can be accelerated by factors like sun exposure, pollution, and oxidative stress. One of the most effective ways to fight back? Antioxidants. Most people are familiar with Vitamin C and Vitamin E in skincare. But there’s a lesser-known antioxidant that research shows may be even more powerful — Idebenone. Not only is Idebenone stronger, but when combined with modern liposomal delivery technology, it can transform how your skin looks and feels. Why Antioxidants Matter for Aging Skin Antioxidants protect your skin from free radicals — unstable molecules caused by UV rays, pollution, stress, and even your body’s natural processes. Free radicals damage collagen, elastin, and cell membranes, leading to: Fine lines and wrinkles Loss of firmness Uneven texture Dullness Crepey skin Think of antioxidants as your skin’s personal bodyguards. They neutralize harmful molecules before they can cause lasting damage. The Usual Antioxidants: Vitamin C and Vitamin E Vitamin C helps brighten skin tone, supports collagen production, and protects against environmental damage. Vitamin E is known for its moisturizing properties and ability to protect cell membranes from oxidative stress. Both are beneficial — but they have limitations. Vitamin C can be unstable and lose potency quickly when exposed to air or light. Vitamin E, while great for moisture, isn’t as effective at neutralizing all types of free radicals. Meet Idebenone: The Supercharged Antioxidant Idebenone is a synthetic analog of Coenzyme Q10, but with a smaller molecular size that allows it to penetrate skin more effectively. Research shows it is one of the most potent antioxidants available — more effective than both Vitamin C and Vitamin E in certain tests. Benefits of Idebenone include: Superior free radical protection from UV exposure and pollution Visible reduction in fine lines and wrinkles Increased skin hydration for smoother texture Support for collagen and elastin to maintain firmness Clinical Research on Idebenone A landmark 2005 study found that women using a 1% Idebenone cream experienced: 29% fewer fine lines and wrinkles 26% reduction in skin roughness 37% increase in hydration Even at 0.5%, Idebenone delivered significant benefits, proving its effectiveness at lower concentrations. Why Liposomal Delivery Matters Even the best antioxidant won’t work if it can’t reach the deeper layers of skin. Liposomal delivery solves this problem. A liposome is a tiny bubble that encapsulates active ingredients like Idebenone. This structure: Helps ingredients penetrate deeper Releases them slowly over time for long-lasting effects Reduces irritation on sensitive skin For women over 50, deeper penetration is key — especially when skin’s barrier function becomes less efficient with age. Idebenone vs. Vitamins C & E Feature Vitamin C Vitamin E Idebenone Antioxidant Power High Moderate Very High Collagen Support Yes Minimal Yes Stability in Formulas Low Moderate High Hydration Boost Minimal High High UV Damage Protection Moderate Moderate High Skin Penetration Moderate Moderate High How to Use Idebenone for Best Results Choose a formula with at least 0.5% to 1% Idebenone and liposomal delivery Apply daily after cleansing and before heavier creams Pair with SPF for maximum protection Combine with hydrating ingredients like hyaluronic acid or ceramides Why This Matters for Women Over 50 After menopause, skin naturally loses collagen, elasticity, and hydration. Antioxidants become essential to slow this process. Idebenone not only protects your skin but also helps restore a smoother, firmer, and more hydrated appearance — especially when delivered deep into the skin with liposomes. Takeaway If you’ve used Vitamin C or E, you’re already helping your skin. But if you want to upgrade your antioxidant protection, Idebenone offers clinically proven results that can take your skincare to the next level. When paired with liposomal delivery, you’re giving your skin the tools it needs to fight back against time, sun, and environmental stress. Shop Hygieia Crepe Repair Cream

Learn more

Fall Skincare Secrets: Why Idebenone is Your Magic Key to Hydrated, Glowing Skin

The Great Fall Skincare Transition: Why Your Skin is Struggling