Crepey Skin Liposomal Repair Cream

Idebenone, a synthetic analog of coenzyme Q10, has been studied for its potential benefits in treating photodamaged skin. A notable clinical trial evaluated the efficacy of topical formulations containing 0.5% and 1.0% idebenone on individuals with moderate photodamage.

Over a six-week period, participants applied the formulations twice daily. The study reported that the 1.0% idebenone formulation led to a 26% reduction in skin roughness and dryness, a 37% increase in skin hydration, a 29% decrease in fine lines and wrinkles, and a 33% overall improvement in the global assessment of photodamaged skin. The 0.5% formulation yielded similar, albeit slightly less pronounced, results.

Additionally, immunofluorescence staining indicated decreases in pro-inflammatory cytokines (IL-1β and IL-6) and matrix metalloproteinase-1 (MMP-1), along with an increase in collagen I expression, suggesting that idebenone may help modulate factors involved in skin aging and damage.

These findings suggest that idebenone can effectively improve various signs of photodamage, including skin texture, hydration, and the appearance of fine lines and wrinkles.

Its antioxidant properties and potential to modulate skin inflammation and collagen production make it a promising ingredient in skincare formulations aimed at addressing photodamaged skin.

If you're a geek you can read the whole pub med study: https://pubmed.ncbi.nlm.nih.gov/17129261

Liposomes are tiny spherical vesicles that have at least one lipid bilayer. They are used in skincare products for several beneficial reasons:

1. Enhanced Delivery of Active Ingredients: Liposomes are designed to encapsulate active ingredients, allowing them to be delivered deep into the skin more effectively than non-encapsulated ingredients. This means that ingredients such as vitamins, antioxidants, and retinol can reach the layers of skin where they can be most beneficial.
2. Improved Stability: Many active ingredients in skincare are sensitive to light, air, or pH changes and can degrade quickly when exposed to these elements. Encapsulating these ingredients in liposomes can protect them from degradation, ensuring that the product remains effective for a longer period.
3. Increased Hydration: The lipid bilayer of liposomes is similar to the lipid bilayer of skin cells, which helps to restore the skin’s natural barrier. This can improve skin hydration by reducing transepidermal water loss, helping to keep skin moisturized and plump.
4. Targeted Delivery: Liposomes can be engineered to target specific areas of the skin, ensuring that active ingredients are released where they are most needed. This targeted delivery can increase the efficacy of skincare products by focusing on areas that require the most attention, such as spots with signs of aging or damage.
5. Reduced Irritation: By encapsulating active ingredients, liposomes can also help to reduce the potential for irritation. This is particularly beneficial for sensitive skin types or when using potent ingredients that could otherwise cause irritation if applied directly to the skin.
6. Compatibility with Skin: Liposomes are biocompatible, meaning they are readily accepted by the skin and unlikely to cause adverse reactions. This makes liposome-based products suitable for a wide range of skin types, including sensitive skin.

In summary, liposomes enhance the effectiveness of skincare products by ensuring that active ingredients are delivered deeply, precisely, and safely into the skin. This leads to improved product performance, offering benefits like increased hydration, reduced signs of aging, and a healthier skin barrier.

Apply cream to wet skin up to twice daily, rub into desired area thoroughly, about 1 min. Allow the cream another min to absorb before applying other products. For added benefit mist with purified water.

Best used with a daily SPF cream for UVA/UVB protection.

Hyaluronic acid is a natural polymer found in skin and joints. It has strong water-attractant properties, so it helps the skin better hold on to moisture. A clinical study from Miami Skin Institute showed that hyaluronic acid improved skin hydration by almost 100% and decreased the depth of wrinkles by up to 40%. These results were observed as early as two weeks into the clinical trial. 

Retinol or vitamin A is crucial for skin health and many people don’t consume enough of it. It activates genes that stimulate cell turnover, increased collagen and elastin production, and reduced excess skin pigmentation. These changes improve skin thickness, strengthen the skin barriers, and put hyaluronic acid and collagen in the right places. Therefore, retinol is an important ingredient for crepey and wrinkle skin repair. 

Glycolic acid turns on skin renewal genes which activate collagen production and increase hyaluronic acid. At the same time, it loosens and exfoliates the stratum corneum layer, allowing other ingredients in the cream to penetrate deeper layers of your skin without compromising the skin barrier. 

Vitamin E is a potent fat-soluble antioxidant that strengthens the skin barrier and protects the skin from sun damage and other sources of day to day oxidative stress.

Idebenone is a water-soluble analog of CoQ10, an anti-aging mitochondria antioxidant and electron carrier. Idebenone enters the mitochondria more readily than CoQ10. Studies have shown that idebenone can jumpstart the mitochondria, which reactivates your skin’s natural repair processes. A clinical study has shown that it reduces fine lines and wrinkles by 29% within 6 weeks of use. 

Collagen is the most abundant structural protein in your body. In your skin, it gives the elastic and youthful appearance. In a clinical study from France, 3% collagen peptides can significantly reduce the number and depth of wrinkles within 4 weeks. 

L-Lysine is an essential amino acid that is a building block of collagen. As a topical skin ingredient, it is an amino acid used in the crosslinking of collagen fibers. 

L-ornithine is an amino acid that doesn’t get used as part of proteins. It stimulates skin regeneration by supporting collagen production and increasing nitric oxide levels. 

L-glutamine is so important that it is the most abundant amino acid in the body. In the skin, it supports balanced immune function and regenerative processes that aid in skin repair. Glutamine also turns on collagen genes and works as a building block for collagen. 

Unlike HGPS, where progerin levels are extremely high, in healthy individuals, progerin accumulates gradually due to:

Alternative Splicing: Low levels of progerin are produced naturally as cells age, contributing to age-related nuclear defects.

Environmental Factors: UV radiation, pollution, and oxidative stress (e.g., from smoking) increase progerin production, accelerating skin and tissue aging.

Telomere Shortening: Aging cells with shorter telomeres show higher progerin levels, linking it to replicative senescence (when cells stop dividing).

Strategies to Mitigate Progerin’s Effects

While progerin itself is challenging to eliminate, its effects can be countered through:

Antioxidants: Ingredients like idebenone (found in Hygieia’s creams), vitamin C, or CoQ10 neutralize ROS, reducing oxidative damage linked to progerin.

Retinoids: Retinol or tretinoin enhance cell turnover and collagen production, countering progerin’s structural damage.

Sun Protection: Broad-spectrum SPF 30+ sunscreen blocks UVA-induced progerin production, a key driver of photoaging.

Hydration and Barrier Support: Ingredients like hyaluronic acid, glycerin & natural oils (like in Hygieia’s creams) maintain skin hydration and barrier function, mitigating progerin’s drying effects.

Many women notice smoother, firmer skin after just one application of Hygieia’s Crepey Skin Repair Cream, but the most significant and lasting results come from daily, consistent use.

That’s why a 1-month supply of Hygieia’s Crepey Skin Repair Cream is a great start, but a 3-month or 6-month supply is even better for sustained benefits.

Many customers report visibly younger, smoother skin within 21 days, with remarkable transformations from incorporating Hygieia into their daily skincare routine.

To support women in maintaining their radiant, youthful look, we offer larger discounts on multi-month supplies & subscriptions for continuous use.